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Methotrexate

Synonyms

Amethopterin | Methotrexat | Méthotrexate | Methotrexate | Methotrexatum | Metotrexato

Common Trade Name

Otrexup

Rasuvo

Rheumatrex

Trexall

Amethopterin

Methotrexate Sodium

MTX

Methotrexate
Generic available

Classification

Antimetabolite

Used For

Methotrexate is a chemotherapy drug that is used to slow or stop cancer cell growth.

 

Acute lymphoblastic leukemia (ALL) Osteosarcoma
Non-Hodgkin's lymphoma (NHL) Choriocarcinoma, chorioadenoma and gestational trophoblastic diseases
Mycosis fungoides (cutaneous T-cell lymphoma) Used in the treatment of breast, advanced head and neck, lung, and stomach cancers
Also used in non-cancerous conditions such as psoriasis and rheumatoid arthritis

How Methotrexate Is Given

  • As an infusion into the vein (intravenous, IV).
  • As an injection into the muscle (intramuscular, IM).
  • Another method is by intraventricular or intrathecal infusion. This method is used when drugs need to reach the cerebrospinal fluid (CSF), the fluid that is surrounding the brain and spinal cord. The drug is infused directly into the spinal fluid.
  • There is also a pill form of methotrexate to be taken by mouth.
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Side Effects

Important things to remember about the side effects of Methotrexate (Table-2) :

 

Table 2 - Side Effects
Low blood counts Mouth sores
Poor appetite Kidney toxicity
Skin rash Diarrhea
Nausea and Vomiting Increases in blood tests measuring liver function
Darkening of the skin where previous radiation treatment has been given Loss of fertility
Alopecia Skin photosensitivity

Relevant Links

Site Map

Synonyms
Common Trade Name
Classification
Used For
Types of Cancer
How Methotrexate is Given
Side Effects
Relevant Links
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